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Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12

Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 83-93 doi: 10.1007/s11684-019-0682-z

Abstract: EGFR accelerate the growth of CRC cells in vitro and in vivo and monoclonal antibody CH12Furthermore, mAb CH12 showed significantly stronger growth suppression activities and induced a morepotent antibody-dependent cellular cytotoxicity effect on CRC cells bearing S492R EGFR than mAb C225.mAb CH12 obviously suppressed the growth of CRC xenografts with S492R EGFR mutations in vivo.Thus, mAb CH12 may be a promising therapeutic agent in treating patients with CRC bearing an S492R EGFR

Keywords： S492R EGFR ectodomain mutation     colorectal cancer     mAb CH12     immunnotherapy    

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The catalytic effect of both oxygen-bearing functional group and ash in carbonaceous catalyst on CH 4

Weidong ZHANG, Yongfa ZHANG,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 2,   Pages 147-152 doi: 10.1007/s11705-009-0242-1

Abstract: A kind of new catalyst—carbonaceous catalyst—for CH-CO reformation has been developed inIt has been found that the carbonaceous catalyst is an efficient catalyst on CO-CH reforming.; the ash components in carbonaceous catalyst also have an important influence on the CO-CH reformingFeO, NaCO, and KCO in the ash can catalyze the CO-CH reforming reaction; CaO has little effect on CO-CHCaO can catalyze the gasification between carbonaceous catalyst and CO; AlO and MgO inhibit the CO-CH

Keywords： oxygen-bearing functional     carboxyl     phenolic hydroxyl     CH-CO reformation     CO-CH reforming    

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Advances of 12th CAPS research symposium: young chemists and chemical engineers fronts

Guoping Hu, Baiqian Dai

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 3,   Pages 461-463 doi: 10.1007/s11705-020-2026-6

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Introduction to the special section on the 12

Zhen-Min CHENG

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 1,   Pages 1-1 doi: 10.1007/s11705-009-0003-1

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Artificial intelligence in gastroenterology: where are we heading?

Joseph JY Sung, Nicholas CH Poon

Frontiers of Medicine 2020, Volume 14, Issue 4,   Pages 511-517 doi: 10.1007/s11684-020-0742-4

Abstract: Artificial intelligence (AI) is coming to medicine in a big wave. From making diagnosis in various medical conditions, following the latest advancements in scientific literature, suggesting appropriate therapies, to predicting prognosis and outcome of diseases and conditions, AI is offering unprecedented possibilities to improve care for patients. Gastroenterology is a field that AI can make a significant impact. This is partly because the diagnosis of gastrointestinal conditions relies a lot on image-based investigations and procedures (endoscopy and radiology). AI-assisted image analysis can make accurate assessment and provide more information than conventional analysis. AI integration of genomic, epigenetic, and metagenomic data may offer new classifications of gastrointestinal cancers and suggest optimal personalized treatments. In managing relapsing and remitting diseases such as inflammatory bowel disease, irritable bowel syndrome, and peptic ulcer bleeding, convoluted neural network may formulate models to predict disease outcome, enhancing treatment efficacy. AI and surgical robots can also assist surgeons in conducting gastrointestinal operations. While the advancement and new opportunities are exciting, the responsibility and liability issues of AI-assisted diagnosis and management need much deliberations.

Keywords： artificial intelligence     endoscopy     robotics     gastrointestinal diseases    

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Online gasoline blending with EPA Complex Model for predicting emissions

Stefan JANAQI, Mériam CHÈBRE, Guillaume PITOLLAT

Frontiers of Engineering Management 2018, Volume 5, Issue 2,   Pages 214-226 doi: 10.15302/J-FEM-2017022

Abstract: The empirical Complex Model developed by the US Environmental Protection Agency (EPA) is used by refiners to predict the toxic emissions of reformulated gasoline with respect to gasoline properties. The difficulty in implementing this model in the blending process stems from the implicit definition of Complex Model through a series of disjunctions assembled by the EPA in the form of spreadsheets. A major breakthrough in the refinery-based Complex Model implementation occurred in 2008 and 2010 through the use of generalized disjunctive and mixed-integer nonlinear programming (MINLP). Nevertheless, the execution time of these MINLP models remains prohibitively long to control emissions with our online gasoline blender. The first objective of this study is to present a new model that decreases the execution time of our online controller. The second objective is to consider toxic thresholds as hard constraints to be verified and search for blends that verify them. Our approach introduces a new way to write the Complex Model without any binary or integer variables. Sigmoid functions are used herein to approximate step functions until the measurement precision for each blend property is reached. By knowing this level of precision, we are able to propose an extremely good and differentiable approximation of the Complex Model. Next, a differentiable objective function is introduced to penalize emission values higher than the threshold emissions. Our optimization module has been implemented and tested with real data. The execution time never exceeded 1 s, which allows the online regulation of emissions the same way as other traditional properties of blended gasoline.

Keywords： emissions     reformulated gasoline     online control     global optimization    

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ThMn12-Type Alloys for Permanent Magnets Review

G.C. Hadjipanayis, A.M. Gabay, A.M. Schönhöbel, A. Martín-Cid, J.M. Barandiaran, D. Niarchos

Engineering 2020, Volume 6, Issue 2,   Pages 140-146 doi: 10.1016/j.eng.2018.12.011

Abstract:

Iron-rich compounds with the tetragonal ThMn12-type structure have the potential to meetdevelopment of underlying magnetic material, this gap has always been unusually large for ThMn12A controlled crystallization of the initially suppressed ThMn12-type phase makes "bulkSm-Fe-V alloys (in which it has been known since the 1990s), but also is in La-added (Ce,Sm)(Fe,Ti)12Mechanochemically synthesized (Sm,Zr)(Fe,Si)12 and (Sm,Zr)(Fe,Co,Ti)12 powders

Keywords： Permanent magnets     Rare earths permanent magnets     ThMn12 structure    

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Major bridge development in Hong Kong, China—past, present and future

Michael CH HUI, Doris YAU

Frontiers of Structural and Civil Engineering 2011, Volume 5, Issue 4,   Pages 405-414 doi: 10.1007/s11709-011-0136-4

Abstract: The first “modern” type of vehicular bridge was built in Hong Kong China in the 1920s. The need for an efficient transportation system to cope with population growth and enable economic development has demanded the construction of more and more bridges since the middle of the 20th century. By 2007, Hong Kong had a total of about 1300 vehicular bridges. Four of these bridges, including the Tsing Ma Bridge, Kap Shui Mun Bridge, Ting Kau Bridge, and the cable-stayed bridge on the Hong Kong- Shenzhen Western Corridor, are considered to be major bridges supported by cables. Currently, the Stonecutters Bridge on Route No. 8 is under construction and is expected to be completed in late 2009. At the same time, the Hong Kong-Zhuhai-Macao Bridge will be in its detailed design stage soon. While efforts have been made by bridge builders to construct these giant structures, the upkeeping of these valuable assets at a high standard and ensuring their continuous functioning and performance during their intended lifespans will be another important task for bridge engineers. Wind and structural health monitoring system (WASHMS) will play a key role in this respect.

Keywords： Tsing Ma Bridge     Kap Shui Mun Bridge     Ting Kau Bridge     Stonecutters Bridge     Hong Kong-Zhuhai-Macao Bridge     wind and structural health monitoring system (WASHMS)    

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Proposed EU legislation to force changes in sewage sludge disposal: A case study

Vojtěch Turek, Bohuslav Kilkovský, Zdeněk Jegla, Petr Stehlík

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 4,   Pages 660-669 doi: 10.1007/s11705-018-1773-0

Abstract:

The consequences of changes planned in the European Union legislation relevant to the disposal of sewage sludges are discussed. A specific municipal waste water treatment plant is analyzed in terms of drying and subsequent combustion or pyrolysis of the produced stabilized sludge, and the respective net energy balances are carried out. A simplified economic analysis of the two disposal options is presented, which suggest that combustion of the sludge would be economically infeasible while pyrolysis of the sludge in a modular, self-sufficient container unit can bring a small financial benefit due to the selling of the produced phosphorus-rich biochar.

Keywords： sewage sludge     drying     combustion     pyrolysis    

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Progress and Prospect of Semiconductor Silicon Wafers in China

Zhang Guohu, Xiao Qinghua, Ma Fei

Strategic Study of CAE 2023, Volume 25, Issue 1,   Pages 68-78 doi: 10.15302/J-SSCAE-2023.01.002

Abstract: This study focuses on the market-dominant 8-inch and 12-inch silicon wafers, analyzes the development

Keywords： semiconductor silicon wafer     8 inches     12 inches     industry synergy     advanced processing    

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Facile controlled synthesis of hierarchically structured mesoporous Li4Ti5O12/C/rGO composites as high-performance

Cehuang FU, Shuiyun SHEN, Ruofei WU, Xiaohui YAN, Guofeng XIA, Junliang ZHANG

Frontiers in Energy 2022, Volume 16, Issue 4,   Pages 607-612 doi: 10.1007/s11708-021-0798-0

Abstract: facile strategy is proposed to controllably synthesize mesoporous Li4Ti5O12graphene matrix as lithium-ion battery anode via the co-assembly of Li4Ti5O12

Keywords： Li4Ti5O12     phenolic-resin-based carbon     mesoporous composite     graphene    

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Poor adherence to P2Y12 antagonists increased cardiovascular risks in Chinese PCI-treated patients

Yang Sun,Chenze Li,Lina Zhang,Dong Hu,Xudong Zhang,Ting Yu,Min Tao,Dao Wen Wang,Xiaoqing Shen

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 53-61 doi: 10.1007/s11684-017-0502-2

Abstract: All patients were followed up at the 1st, 6th, and 12th month of discharge while recording ATM and majorcoronary artery bypass grafting (CABG) alone had significantly lower proportion of high adherence to P2Y12Moreover, in patients undergoing PCI, high adherence to P2Y12 antagonists decreased the risk of MACEHigh adherence to P2Y12 antagonists was associated with lower risk of MACE.

Keywords： acute coronary syndromes     adherence to secondary prevention medications     clinical outcome    

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AC-DC Power Integration Techniques

Ma Weiming

Strategic Study of CAE 2002, Volume 4, Issue 12,   Pages 53-59

Abstract: electric power integration, wherein the stator with one set of 3-phase AC winding and another set of 12together with a rotor having a d-axis field winding and a q-axis stabilizing winding, is combined with a 12Due to complete electrical separation of the AC and DC circuits and usage of the properly designed 12The principle and methods for on-line real time fault diagnosis of the diodes in the 12-phase rectifier

Keywords： electric power integration     double-winding AC - DC generator     12-phase rectification     simultaneous AC and    

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Wheat Blast Pathogen Magnaporthe Oryzae Triticum Pathotype Using Genome-Specific Primers and Cas12a-mediated Article

Houxiang Kang, Ye Peng, Kangyu Hua, Yufei Deng, Maria Bellizzi, Dipali Rani Gupta, Nur Uddin Mahmud, Alfredo S. Urashima, Sanjoy Kumar Paul, Gary Peterson, Yilin Zhou, Xueping Zhou, Md Tofazzal Islam, Guo-Liang Wang

Engineering 2021, Volume 7, Issue 9,   Pages 1326-1335 doi: 10.1016/j.eng.2020.07.016

Abstract: Following this, we used the Cas12a protein and guide RNAs (gRNAs) to target the MoT-6098 and MoT-6099The activated Cas12a showed indiscriminate single-stranded DNase (ssDNAase) activity.We then combined target-dependent Cas12a ssDNase activation with recombinase polymerase amplification

Keywords： Wheat blast     Magnaporthe oryzae     Triticum Cas12a     Nucleic acid rapid lateral flow immunoassay     Field    

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Real time monitoring of bioreactor mAb IgG3 cell culture process dynamics via Fourier transform infrared

Huiquan Wu, Erik Read, Maury White, Brittany Chavez, Kurt Brorson, Cyrus Agarabi, Mansoor Khan

Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 3,   Pages 386-406 doi: 10.1007/s11705-015-1533-3

Abstract: In this work, real time inline FTIR Spectroscopy was applied to a lab scale bioreactor mAb IgG3 cell

Keywords： process analytical technology (PAT)     Fourier-transform infrared (FTIR) spectroscopy     partial least squares (PLS) regression     mouse IgG3     bioreactor cell culture process     real time process monitoring    

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Title Author Date Type Operation

Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12

Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang

Journal Article

The catalytic effect of both oxygen-bearing functional group and ash in carbonaceous catalyst on CH 4

Weidong ZHANG, Yongfa ZHANG,

Journal Article

Advances of 12th CAPS research symposium: young chemists and chemical engineers fronts

Guoping Hu, Baiqian Dai

Journal Article

Introduction to the special section on the 12

Zhen-Min CHENG

Journal Article

Artificial intelligence in gastroenterology: where are we heading?

Joseph JY Sung, Nicholas CH Poon

Journal Article

Online gasoline blending with EPA Complex Model for predicting emissions

Stefan JANAQI, Mériam CHÈBRE, Guillaume PITOLLAT

Journal Article

ThMn12-Type Alloys for Permanent Magnets

G.C. Hadjipanayis, A.M. Gabay, A.M. Schönhöbel, A. Martín-Cid, J.M. Barandiaran, D. Niarchos

Journal Article

Major bridge development in Hong Kong, China—past, present and future

Michael CH HUI, Doris YAU

Journal Article

Proposed EU legislation to force changes in sewage sludge disposal: A case study

Vojtěch Turek, Bohuslav Kilkovský, Zdeněk Jegla, Petr Stehlík

Journal Article

Progress and Prospect of Semiconductor Silicon Wafers in China

Zhang Guohu, Xiao Qinghua, Ma Fei

Journal Article

Facile controlled synthesis of hierarchically structured mesoporous Li4Ti5O12/C/rGO composites as high-performance

Cehuang FU, Shuiyun SHEN, Ruofei WU, Xiaohui YAN, Guofeng XIA, Junliang ZHANG

Journal Article

Poor adherence to P2Y12 antagonists increased cardiovascular risks in Chinese PCI-treated patients

Yang Sun,Chenze Li,Lina Zhang,Dong Hu,Xudong Zhang,Ting Yu,Min Tao,Dao Wen Wang,Xiaoqing Shen

Journal Article

AC-DC Power Integration Techniques

Ma Weiming

Journal Article

Wheat Blast Pathogen Magnaporthe Oryzae Triticum Pathotype Using Genome-Specific Primers and Cas12a-mediated

Houxiang Kang, Ye Peng, Kangyu Hua, Yufei Deng, Maria Bellizzi, Dipali Rani Gupta, Nur Uddin Mahmud, Alfredo S. Urashima, Sanjoy Kumar Paul, Gary Peterson, Yilin Zhou, Xueping Zhou, Md Tofazzal Islam, Guo-Liang Wang

Journal Article

Real time monitoring of bioreactor mAb IgG3 cell culture process dynamics via Fourier transform infrared

Huiquan Wu, Erik Read, Maury White, Brittany Chavez, Kurt Brorson, Cyrus Agarabi, Mansoor Khan

Journal Article